![]() The oral pregabalin may attenuate the hemodynamic pressor response with intraoperative hemodynamic stability. Preoperative administration of oral pregabalin in a single dose of 150 mg appears to be effective to significantly reduce the anxiety of patients, intraoperative hemodynamic changes, and postoperative pain.Clinical relevanceThese findings suggest that pregabalin is useful and safe for preoperative and intraoperative anxiety control in patients undergoing surgery.īackground: Attenuation of anxiety and stress response to endotracheal intubation are the cornerstone of good anaesthetic outcome. It is not associated with any severe adverse effects.Conclusion ![]() A dose of 75 mg preoperative oral pregabalin has been found to reduce anxiety and stabilize intraoperative hemodynamics, although a more significant improvement appears to be achieved with a single dose of 150 mg pregabalin at least 1 h before the surgery. All twelve studies were trials of high quality. Based on PRISMA guidelines, the specific question was: is preoperative oral pregabalin effective and safe for anxiety control in patients undergoing surgery? The critical reading of retrieved studies followed questions prepared by the CASPe Network, and their methodological quality was evaluated using the Jadad Scale.ResultsTwelve randomized controlled trials were selected for review. ![]() The objective of this systematic review was to determine the effectiveness of preoperative oral pregabalin for anxiety control, the most effective dosage regimen, its impact on postoperative pain, and its adverse effects.Materials and methodsA search was conducted of PubMed/Medline and (National Library of Medicine, Washington, DC), Scopus, Web of Science, and Cochrane databases for studies published between January 2009 and November 2018, with no language restriction. The premedicated patients were haemodynamically stable perioperatively without prolongation of recovery time and side-effects. The haemodynamic pressor response of airway instrumentation was attenuated in a dose-related fashion. ![]() Oral pregabalin premedication has adequately sedated the patients. None of the patient has suffered from any post-operative side-effects, and no significant differences in the parameters of recovery and awakening time were observed. No significant decrease in heart rate was observed in any group. Significant increase in heart rate and mean arterial pressure was observed in Groups I and II after airway instrumentation, while statistically significant attenuation of mean arterial pressure was seen in Group III. Pre-operative sedation levels were higher with pregabalin premedication. ![]() Anaesthetic technique was standardized and all groups were assessed for pre-operative sedation, haemodynamic changes after the premedication, before and after induction, after laryngoscopy and intubation, along with intraoperative haemodynamic stability and post-operative side-effects. Group I received oral placebo, Group II oral pregabalin 75 mg and Group III oral pregabalin 150 mg 1 h prior to induction. The present study evaluated the safe and clinically effective dose of oral pregabalin premedication for attenuation of haemodynamic pressor response of airway instrumentation.Ī total of 90 normotensive adult consented patients aged 24-56 years, ASA grade I and II, of both gender were randomized into three treatment groups of 30 patients each. The airway instrumentation of direct laryngoscopy and tracheal intubation are powerful noxious stimuli that should be attenuated by appropriate premedication, smooth induction and rapid intubation. ![]()
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